The round five encounter in Durban starts at 19h00 and will be televised live on the SuperSport Rugby and Grandstand channels.
With regular captain Lukhanyo Am unavailable for selection due to a hand injury that will see him out for approximately four weeks, Venter (flanker) will take over the captaincy armband for this match against his former team, as the Cell C Sharks head coach Sean Everitt looks to keep intact a winning group.
Am picked the hand injury in last weekend's fourth round away victory over the Phakisa Pumas.
However, the good news is that Sikhumbuzo Notshe (No 8) has been cleared fit after sustaining a hamstring strain against the Vodacom Bulls and after missing out the win last weekend in Nelspruit, and has been named on a bench laden with forwards.
Everitt has selected a 6-2 split amongst the replacements in anticipation of a highly contested physical forward battle.
With Am out, Jeremy Ward gets a start ata outside centre, with Yaw Penxe taking over from another Springbok, Sbu Nkosi, who misses out due to a slight niggle. Former Blitzbok star Werner Kok has been named on the bench.
Apart from Am and Nkosi, the Cell C Sharks also have Aphelele Fassi (fullback), James Venter (loose forward) and Springbok Thomas du Toit (prop) unavailable due to injuries.
Cell C Sharks: 15 Manie Libbok, 14 Yaw Penxe, 13 Jeremy Ward, 12 Marius Louw, 11 Madosh Tambwe, 10 Curwin Bosch, 9 Sanele Nohamba, 8 Phepsi Buthelezi, 7 Henco Venter (captain), 6 Dylan Richardson, 5 Hyron Andrews, 4 JJ van der Mescht, 3 John-Hubert Meyer, 2 Dan Jooste, 1 Ox Nche. Replacements: 16 Kerron van Vuuren, 17 Mzamo Majola, 18 Michael Kumbirai, 19 Ruben van Heerden, 20 Thembelani Bholi, 21 Sikhumbuzo Notshe, 22 Grant Williams, 23 Werner Kok.
Match information - Cell C Sharks v Toyota Cheetahs
Date: Friday, 6 November 2020
Venue: Jonsson Kings Park, Durban
Referee: Cwengile Jadezweni
Assistant Referees: Marius van der Westhuizen, Paul Mente
Television Match Official: Marius Jonker
TV: SuperSport Rugby and Grandstand