The Jukskei derby, which will mark the second successive match-up between the Vodacom Bulls and Xerox Lions at Loftus Versfeld in Pretoria, will begin at 14h00.
All eyes will then switch to DHL Newlands in Cape Town for the semi-final between DHL Western Province and the Cell C Sharks at 16h30.
The two winning teams will battle it out in the final on Saturday, 30 January.
The dates of the semi-finals and final were moved out by a week respectively as a precautionary measure to ensure tournament integrity and allow the participants to manage COVID-19 challenges.
With defending champions, the Toyota Cheetahs, dropping out at the conclusion of the pool stage, a new Carling Currie Cup champion will be crowned this season.