The match in Cape Town between the traditional northern and southern rivals kicks off at 19h00 and will be broadcast live on SuperSport.
The recently crowned Vodacom Super Rugby Unlocked champions now set their sights on the Carling Currie Cup which the Pretoria franchise last won in 2009, and they will be determined to bag a full house of points in what marks DHL Newlands' swansong season.
Vodacom Bulls Director of Rugby, Jake White has tweaked his match day squad with the inclusion of Grobbelaar, while Chris Smith retains the No 10 jersey after an impressive showing last week.
The rest of the starting line-up from their victory over the Phakisa Pumas remains unchanged.
Amongst the replacements, Corniel Els shifts to the bench and will provide cover at hooker, while Clinton Swart retains the number 22 jersey.
"We achieved our first goal of the post-pandemic season and now we shift our focus to securing the Currie Cup with a massive target on our backs," said White.
"There are a few teams that can travel to Newlands as favourites, which makes our job harder. Couple that with the fact that Western Province are always a difficult team to face, home or away, and fans can expect a true old school North-South Derby."
Vodacom Bulls: 15 David Kriel, 14 Travis Ismaiel, 13 Stedman Gans, 12 Cornal Hendricks, 11 Kurt-Lee Arendse, 10 Chris Smith, 9 Ivan van Zyl, 8 Duane Vermeulen (captain), 7 Arno Botha, 6 Marco van Staden, 5 Ruan Nortje, 4 Walt Steenkamp, 3 Trevor Nyakane, 2 Johan Grobbelaar, 1 Jacques van Rooyen. Replacements: 16 Corniel Els, 17 Gerhard Steenekamp, 18 Marcel van der Merwe, 19 Sintu Manjezi, 20 Nizaam Carr, 21 Embrose Papier, 22 Clinton Swart, 23 Marco Jansen van Vuren.
Match information - DHL Western Province v Vodacom Bulls
Date: Saturday, 28 November 2020
Venue: DHL Newlands, Cape Town
Referee: AJ Jacobs
Assistant referees: Cwengile Jadezweni, Divan Uys
Television Match Official: Rasta Rasivhenge
TV: SuperSport Grandstand and Rugby