The match will be broadcast live on SuperSport at 16h15, with Rasta Rasivhenge holding the whistle, while AJ Jacobs and Griffin Colby will serve as assistant referees and Marius van der Westhuizen as the TMO.
The Lions backline has a familiar look to it with Tiaan Swanepoel reverting to fullback, while Wandisile Simelane and Burger Odendaal will lead the charge in the midfield, with Jantjies calling the shots from the pivot position.
Youngster Ngia Selengbe, meanwhile, earns a start on the right wing after his eye-catching performance in the win against Eastern Province.
Up front, Willem Alberts (lock), Ruan Dreyer and Carlü Sadie (props) are among a few players returning to action.
On the replacements bench flyhalf Fred Zeilinga will try to impress in what marks his trial spell in Johannesburg after having represented the Cell C Sharks and Toyota Cheetahs between 2011 and 2018, and more recently Japanese club, the Canon Eagles.
Lions: 15 Tiaan Swanepoel, 14 Ngia Selengbe, 13 Wandisile Simelane, 12 Burger Odendaal, 11 Courtnall Skosan, 10 Elton Jantjies (captain), 9 André Warner, 8 Francke Horn, 7 Vincent Tshituka, 6 MJ Pelser, 5 Wilhelm van der Sluys, 4 Willem Alberts, 3 Carlü Sadie, 2 Jan-Henning Campher, 1 Ruan Dreyer. Replacements: 16 PJ Botha, 17 Nathan McBeth, 18 Jannie du Plessis, 19 Reinhard Nothnagel, 20 Sibusiso Sangweni, 21 Ross Cronjé, 22 Fred Zeilinga, 23 Dan Kriel.