The Emirates Airline Park fixture starts at 19h00 and is the Emirates Lions first home match of the new campaign, 258 days since their previous match on home turf before the season was suspended due to COVID-19.
Jantjies was not considered for his side’s encounter last weekend against the Toyota Cheetahs because of the leg injury, but the match was eventually called off in line with COVID-19 protocols.
It was confirmed that Friday evening's clash would go ahead following consultation between SA Rugby and the National Institute for Communicable Diseases (NCID).
Other changes to the Emirates Lions side include the selection of a brand new back trio of Gianni Lombard, Stean Pienaar and Courtnall Skosan.
Lombard comes into the side in place of EW Viljoen at fullback, while speedsters Pienaar is preferred over Jamba Ulengo, and Skosan starts instead of Rabz Maxwane.
The Joburg-based franchise also named a strong bench for the home encounter, consisting of PJ Botha, Ruan Dreyer, Jannie du Plessis, Reinhard Nothnagel, Jaco Kriel, Ross Cronjé, Burger Odendaal and Tiaan Swanepoel.
Earlier on Friday, the SA Rugby Under-21 Championship Final between the Xerox Lions U21 and defending champions, the Vodacom Blue Bulls U21, starts at 14h00 at the same venue.
Emirates Lions: 15 Gianni Lombard; 14 Stean Pienaar, 13 Wandisile Simelane, 12 Dan Kriel, 11 Courtnall Skosan; 10 Elton Jantjies (captain), 9 Morné van den Berg; 8 Len Massyn, 7 Vincent Tshituka, 6 MJ Pelser, 5 Marvin Orie, 4 Ruben Schoeman, 3 Carlu Sadie, 2 Jaco Visagie, 1 Sti Sithole. Replacements: 16 PJ Botha, 17 Ruan Dreyer, 18 Jannie du Plessis, 19 Reinhard Nothnagel, 20 Jaco Kriel, 21 Ross Cronjé, 22 Burger Odendaal, 23 Tiaan Swanepoel.
Match information – Emirates Lions v Tafel Lager Griquas
Date: Friday, 30 October 2020
Venue: Emirates Airline Park, Johannesburg
Referee: Marius van der Westhuizen
Assistant referees: Aimee Barrett-Theron, Stuart Berry
Television Match Official: Jaco Peyper
TV: SuperSport Grandstand and Rugby