The KwaZulu-Natalians have returned home to Jonsson Kings Park brimming with confidence following three good victories on the road in New Zealand and Australia.
Last week, Cell C Sharks head coach Sean Everitt rested flankers James Venter and Tyler Paul, and both have been restored to the starting line-up alongside Nkosi, who has regained fitness following his injury layoff.
The return of the Springbok wing means a shift to the bench for Madosh Tambwe, who has performed admirably in his absence.
Meanwhile, the Jaguares will feel confident of a good performance in Durban following their success over the Vodacom Bulls last weekend in Pretoria.
The Argentineans have won three of their last four outings in the Republic, while the Cell C Sharks will be out to break a run of three home losses to teams from outside South Africa.
Cell C Sharks: 15 Aphelele Fassi, 14 Sibusiso Nkosi, 13 Lukhanyo Am (captain), 12 Andre Esterhuizen, 11 Makazole Mapimpi, 10 Curwin Bosch, 9 Louis Schreuder, 8 Sikumbuzo Notshe, 7 Tyler Paul, 6 James Venter, 5 Hyron Andrews, 4 Ruben van Heerden, 3 Thomas du Toit, 2 Kerron van Vuuren, 1 Ox Nche. Replacements: 16 Craig Burden, 17 Juan Schoeman, 18 John-Hubert Meyer, 19 Le Roux Roets, 20 Henco Venter, 21 Sanele Nohamba, 22 Jeremy Ward, 23 Madosh Tambwe.
Jaguares – 15 Joaquin Tuculet, 14 Santiago Carreras, 13 Matias Moroni, 12 Jeronimo De La Fuente (captain), 11 Emiliano Boffelli, 10 Joaquin Diaz Bonilla, 9 Gonzalo Bertranou, 8 Rodrigo Bruni, 7 Marcos Kremer, 6 Tomas Lezana, 5 Matias Alemanno, 4 Guido Petti Pagadizaval, 3 Joel Sclavi, 2 Julian Montoya, 1 Mayco Vivas. Replacements: 16 Santiago Socino, 17 Nahuel Tetaz Chaparro, 18 Santiago Medrano, 19 Lucas Paulos, 20 Santiago Grondona, 21 Sebastian Cancelliere, 22 Domingo Miotti, 23 Santiago Chocobares.
Head to head:
Cell C Sharks won: 5
Jaguares won: 3
Cell C Sharks points: 152
Jaguares points: 199
Average score: 19-25
Date: Saturday, 7 March
Venue: Jonsson Kings Park, Durban
Kick-off: 15h05 (SA time)
Referee: Marius van der Westhuizen (South Africa)
Assistant referees: Egon Seconds (South Africa), Aimee Barrett-Theron (South Africa)
TMO: Joey Klaaste-Salmans (South Africa)