Creevy replaces Julian Montoya in the starting line-up after missing their recent defeat to Australia. He will also captain the side.
In other changes to the pack, Marcos Kremer comes in at lock for Guido Petti while flank Tomas Lezana drops out for Javier Ortega Desio.
There is only one change to the backline. Emiliano Boffelli comes in at fullback with Joaquin Tuculet dropping down to the replacements bench.
The Pumas have lost both their Castle Lager Rugby Championship games so far in the competition and face a Springbok side looking to seal the championship title in Salta.
The teams have played each other 28 times, with the Pumas winning three times.
Their last fixture in Salta was in 2017, where South Africa won 41-23, while in 2016, Argentina scored a 26-24 win at Estadio Padre Ernesto Martearena.
The Pumas team: 15 Emiliano Boffelli, 14 Santiago Cordero, 13 Matias Moroni, 12 Jeronimo de la Fuente, 11 Ramiro Moyano, 10 Nicolas Sanchez, 9 Tomas Cubelli, 8 Facundo Isa, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Marcos Kremer, 4 Matias Alemanno, 3 Juan Figallo, 2 Agustin Creevy, 1 Nahuel Tetaz Chaparro. Replacements: 16 Julian Montoya, 17 Mayco Vivas, 18 Santiago Medrano, 19 Guido Petti, 20 Tomas Lezana, 21 Gonzalo Bertanou, 22 Benjamin Urdapilleta, 23 Joaquin Tuculet.