The Scottish fullback will lead an all-new starting XV to the one that defeated Japan 28-10 in Edinburgh last weekend, save for Josh Adams (Wales) who retains his place on the left wing.
Louis Rees-Zammit (Wales), Chris Harris (Scotland), Hamish Watson (Scotland) and Jonny Hill (England) are all set to make their Lions debuts at Emirates Airline Park in Johannesburg, in the first of eight Tour games.
Replacements Luke Cowan-Dickie (England), Zander Fagerson (Scotland), Sam Simmonds (England) and Gareth Davies (Wales) are also in line to make their first appearances in the famous red jersey should they join the fray on Saturday.
“It’s good to have arrived in Johannesburg and get the Tour underway,” said Lions head coach, Warren Gatland.
“We had a pleasing win last week up in Edinburgh, but there’s still plenty we need to get right on Saturday.
“I’ve been encouraged by the way the boys have trained this week. I feel it’s gone up a level from where we were in Jersey and we’re starting to see a better understanding of some of our tactics.
“There’s some new player combinations for us to have a look at this Saturday – which is good information for us as the Test Series approaches.
“My congratulations to all those playing their first game as a Lion, and also to Hoggy too – who I am sure will lead the side by example.”
British & Irish Lions: 15 Stuart Hogg (captain), 14 Louis Rees-Zammit, 13 Chris Harris, 12 Owen Farrell, 11 Josh Adams, 10 Finn Russell, 9 Ali Price, 8 Taulupe Faletau, 7 Hamish Watson, Courtney Lawes, 5 Jonny Hill, 4 Maro Itoje, 3 Kyle Sinckler, 2 Jamie George, 1 Wyn Jones. Replacements: 16 Luke Cowan-Dickie, 17 Mako Vunipola, 18 Zander Fagerson, 19 Iain Henderson, 20 Sam Simmonds, 21 Gareth Davies, 22 Bundee Aki, 23 Elliot Daly.